Extended Data Fig. 15: Further analysis for LPC mouse brains.
From: Spatial dynamics of brain development and neuroinflammation
a-b, CellChat dot plot showing representative ligand–receptor interactions among microglial subclusters (MC1–MC3) and other brain cell types at 5 DPL (a) and 10 DPL (b). Bubble colour represents communication probability, and bubble size indicates statistical significance (p < 0.01; 0.01 ≤ p < 0.05). Statistical significance was assessed using CellChat’s built-in permutation test on communication probability (one-sided; alternative hypothesis: probability > 0). c, Communication networks of microglial subtypes and brain cell types, based on CellChat analysis. d, Representative spatial maps of ligand–receptor interaction showing regional enrichment within lesion-like compartments at 10 DPL. e, Spatial mapping of gene expression and ATAC GAS for the genes in d and Fig. 6m.
