Fig. 4: Comparison of T2D GWAS results in the TPMI with those from four biobanks.
From: The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies
a, Comparison of GWAS results from the TPMI and the PheWebs of the Biobank Japan (BBJ), China Kadoorie Biobank (CKB), the Korean Genome and Epidemiology Study (KoGES) and the UK Biobank (UKB). A Firth logistic regression was applied for the T2D GWAS in the TPMI. All statistical tests were two-sided. Multiple-testing adjustment was applied using a genome-wide significance threshold of P < 1 × 10−8. Novel T2D-associated SNPs identified in our GWAS but absent in biobanks at the genome-wide significance level are shown. b, Pairwise comparison with each biobank. Different statistical methods were applied across cohorts. For BBJ, CKB and KoGES, a generalized linear mixed model was implemented using SAIGE; for UKB: linear regression was used. All tests were two-sided. Bonferroni correction was applied for multiple-testing adjustment across loci. The four graphs (from top to bottom) show T2D-associated SNPs identified in the TPMI but not in BBJ, CKB, KoGES and UKB, respectively.
