Extended Data Fig. 8: Transcriptomic analysis of DNA repair pathway genes across species.
From: Evidence for improved DNA repair in the long-lived bowhead whale
Heatmap of relative gene expression levels for components of six major DNA repair pathways across species. Z-scores are scaled by row (gene), allowing comparison of expression patterns across species. Within each pathway, genes are ordered by decreasing expression in the bowhead whale. Genes that show higher expression in the bowhead whale compared to all three other species are labelled in red text to the right of the heatmap. Gene sets for each pathway were compiled from three sources: the MSigDB database, Gene Ontology (GO) annotations, and a curated list of human DNA repair genes from the Wood Laboratory at MD Anderson Cancer Center (www.mdanderson.org/documents/Labs/Wood-Laboratory/human-dna-repair-genes.html).
