Extended Data Fig. 3: Combined effect of common and rare variants on ADHD risk.
From: Rare genetic variants confer a high risk of ADHD and implicate neuronal biology
Risk for ADHD is given on the y-axis (Dots represent beta coefficient point estimates from logistic regression, and error bars indicate the corresponding 95% confidence intervals [CI]) across ADHD-PGS pentiles on the x-axis, in individuals with no rare class I variants in constrained autosomal genes (pLI ≥ 0.9; marked in green) (n = 14,634 individuals) and in individuals with 1 or more class I variants in constrained autosomal genes (pLI ≥ 0.9; marked in orange) (n = 3,262 individuals). The beta (β) score across groups is relative to the risk in ADHD-PGS pentile one of individuals with no rare class I variants in constrained autosomal genes.
