Extended Data Fig. 4: Effect of rare variants on comorbidity in ADHD across pLI bins.
From: Rare genetic variants confer a high risk of ADHD and implicate neuronal biology
Burden (odds ratio; OR) of rare class I, class II and rare synonymous variants (SYN) in individuals with ADHD and comorbidities compared to individuals without the comorbid condition being analysed across pLI bins. Results are from logistic regression (detailed results in Supplementary Table 19). a, ADHD with intellectual disability (ID) compared to ADHD with no ID. b, ADHD comorbid with autism spectrum disorder (ASD) compared to ADHD without ASD. c, ADHD comorbid with schizophrenia (SZ) compared to ADHD without SZ. d, ADHD with multimorbidities compared to ADHD without multimorbidities. e, ADHD with no ID compared to controls. f, ADHD without multimorbidities compared to controls without multimorbidities. *Indicates nominal significant association P < 0.05, **Indicates significant association after Bonferroni correction (correcting for three gene sets; P values less than P = 0.0167 are considered significant).
