Fig. 2: 3D histology reconstruction of Case 1.
From: A probabilistic histological atlas of the human brain for MRI segmentation
a, Coronal slice of 3D reconstruction; boundaries between blocks are noticeable from uneven staining. Joint registration minimizes overlap and and gaps between blocks (this reconstructed slice comprises four different blocks). b, Accurate intermodality registration with artificial intelligence techniques. Registered MRI, LFB and H&E histology of a block, with tissue boundaries (traced on LFB) overlaid. c, Orthogonal view of reconstruction, which is smooth thanks to the Bayesian refinement and avoids gaps and overlaps thanks to the regularizer. d, Visualization of 3D landmark registration errors for Case 1. Left, visualization of landmarks. Right, histogram, mean and s.d. of error magnitude for this case, compared with our previous pipeline. Error (mean ± s.d.): 1.27 ± 0.59 mm. Error26: 1.42 ± 0.72 mm. See Table 1 and Extended Data Figs. 1, 2, 3 and 4 for results on the other cases.
