Extended Data Fig. 10: SIGLEC12 mutations and the proposed model of TMPRSS4-mediated SIGLEC12 activation during necroptosis. | Nature

Extended Data Fig. 10: SIGLEC12 mutations and the proposed model of TMPRSS4-mediated SIGLEC12 activation during necroptosis.

From: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death

Extended Data Fig. 10: SIGLEC12 mutations and the proposed model of TMPRSS4-mediated SIGLEC12 activation during necroptosis.The alternative text for this image may have been generated using AI.

a, Summary of the SIGLEC12 mutation frequencies found in the general population (graphs) and their location in the SIGLEC12 domains. Green circles: extracellular mutations; Red circle: cancer-associated mutation S458F; Yellow circles: intracellular mutations; TM: transmembrane region. Blue boxes: V-type Ig domains; Green boxes: C2-type Ig domains; Orange boxes: ITIM and ITSM domains; Red box: NISI motif. b, A proposed model of SIGLEC12 activation and plasma membrane rupture induction during necroptosis. Panels a and b were created using Biorender (https://biorender.com).

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