Extended Data Fig. 8: Cellular co-localisation in Crohn’s fistulae.

Related to Fig. 2. A. Cell type co-localisation network plot visualising cell subsets identified in Xenium ST cohort (n = 53 total samples) in healthy control tissue sections. Edges represent degree of co-localisation between two cell types, node size indicates the overall abundance of the cell type, nodes are coloured by cell lineage. Graph edges with low degree of co-localisation between cell type pairs (<0.15) are omitted for clarity. B. As in A, except for inflammatory CD tissue sections. C. As in A, except for diverticular disease fistulae tissue sections. D. As in A, except for external, perianal fistulae tissue sections. E. As in A, except for internal, non-peri anal non-epithelialised fistula tissue sections. F. As in A, except for internal, epithelialised fistula tissue sections. G. As in A, except for external, epithelialised fistula tissue sections. H. As in A, except for external, non-epithelialised fistula tissue sections.