Extended Data Fig. 8: In vivo characterization of ketamine analogues: adenosine release and locomotor activity.
From: Adenosine signalling drives antidepressant actions of ketamine and ECT
a, Chemical structures of the synthesized ketamine analogues. b, Heatmap of peak adenosine signal (upper) and AUC (lower) in the mPFC following administration of each analogue (10 mg·kg−1, i.p.). All values are normalized to the response induced by an equivalent dose of ketamine. c, Locomotor activity time course after ketamine or DCK administration. Baseline recorded for 15 min; i.p. injection at dashed line; activity monitored for 75 min post-injection. Mouse sample sizes (n) are shown near the data series. d, Dose-dependent increase in locomotor activity induced by ketamine and DCK. Data are mean ± s.e.m. (c, d). Two-tailed unpaired t-tests between drugs and saline control (*P < 0.05, ***P < 0.001). See Supplementary Table 1 for detailed statistics.
