Extended Data Fig. 10: Acute intermittent hypoxia (aIH) alleviates depressive-like phenotypes through adenosine signaling.
From: Adenosine signalling drives antidepressant actions of ketamine and ECT
a, Experimental timeline for acute intermittent hypoxia (aIH) exposure in mice. b, Oxygen-dependent adenosine dynamics in the mPFC, monitored with GRABAdo1.0 sensor during graded hypoxia (9–21% O2; n = 11 mice). c-e, Experimental paradigm for assessing aIH antidepressant efficacy (c), FST immobility time (d), and sucrose preference (e) of CRS-challenged WT, A1 KO and A2A KO mice. f, Open-field locomotor activity in WT, adenosine receptor A1 KO and A2A KO mice before and after aIH following CRS. Data are mean ± s.e.m. (shading in b; error bars in d–f). Two-tailed unpaired t-tests were used for d–f (***P < 0.001). See Supplementary Table 1 for detailed statistics. The schematics in a and c were created using BioRender (https://www.biorender.com).
