Extended Data Fig. 5: Impact of ENU mutational signature on Ctnnb1.
From: Decay of driver mutations shapes the landscape of intestinal transformation
a, Predicted frequency (expected) of Ctnnb1 exon 3 mutations from mutational preference for primed (TE) cohorts. b, Observed frequency of Ctnnb1 exon 3 mutations identified for TE cohorts. c, Observed/expected ratios for β-catenin driver aa change (n > 9). d, Predicted frequency (expected) of Ctnnb1 exon 3 mutations from mutational preference for all cohorts. e, Observed frequency of Ctnnb1 exon 3 mutations identified for all cohorts. f, Observed/expected for all β-catenin driver aa changes. P-values were derived using a chi-squared test for each mutation (df=1).
