Extended Data Fig. 7: Apc mutation overview for all cohorts.
From: Decay of driver mutations shapes the landscape of intestinal transformation
a, Plot showing expected and observed relative frequencies for each Apc codon in N-terminal half (aa 1–1,586) for all cohorts. Frequencies were normalized against most expected and observed stop codon position (encoding W155 for both). b, Plot showing truncation position in APC for each tumour or clone and linked N- and C-terminal truncation locations from cases where different mutations are paired for all cohorts except Apchet. Dashed lines separate bin (black) and domain/repeats (blue) boundaries depicted in legend below. MCR: mutation cluster region in human CRC.
