Extended Data Fig. 9: Apc mutation analysis in rescue protocol.
From: Decay of driver mutations shapes the landscape of intestinal transformation
a, Heatmap with count data for Apc domain bins in relation to protocol for each cohort. b, Heatmap with count data for Apc domain bins in relation to protocol for combined KrasG12D, Trp53null, and Fbxw7null (KTF) cohorts. c, Heatmap with count data for Apc domain bins in relation to protocol for Apchet cohort. d, Plot showing truncation position in the Apc gene for each tumour or clone and linked N- and C-terminal truncation locations from cases where different mutations are paired in KTF and control cohorts and compared throughout different protocols. e, Heatmap with count data for each bin combination in (d) for cohorts shown. Letters define N- and C-terminal bin combinations. f, Proportion of tumours remaining in rescue protocol with bin combinations containing bin A, B, C, D, or E compared to all but respective bin combination non-A, non-B, non-C, non-D, or non-E in relation to priming protocol for KTF cohort. Dashed line models neutral clonal decay in proximal SI. P-values in (a, b, c, e) were derived using Fisher’s exact test (two-sided). P-values in panel (f) were derived for each rescue time-point using a chi-squared test (df=1) for each APC bin combination.
