Extended Data Fig. 5
From: Somatic evolution following cancer treatment in normal tissue
A. Relationship between temozolomide-related mutations per cell per Mb and the days of temozolomide treatment. Each dot represents a sample. B. Treatment history of CRUKP0279. Two time-points at which blood was sampled are highlighted in red. C. Top, the mutational spectra of single-base substitutions at time point A, with the signature exposures depicted on the right. Bottom, the mutational spectra of single-base substitutions at time point B, and the signature exposures depicted on the right. D. Mutational profile of SBS-J.
