Extended Data Fig. 7

A. Distribution of observed driver mutations, as defined either by truncating, frameshift, or AlphaMissense score > 0.56, across the length of the TP53 and PPM1D gene in blood, liver and lung tissues. Y axis represents the VAF of the observed mutations. The color represents the tissue, the shape highlights the consequence type of mutation. In blue, the protein domains as defined by pFam are depicted. Sequenced exons are represented in orange, separated by black bars. At the bottom, the driver density across the gene body is depicted. B dNdS ratios for all mutations, those supported by at least 2 reads or supported by 3 reads, across the whole cohort or only in TP53. Lines represent the confidence intervals (CI). C. Global dNdScv rations across tissues. Lines represent the confidence intervals (CI). When the lower CI is above 1, we deem this tissue as being under global positive selection. D. Distribution of driver mutations in NFE2L2, BRAF and CTNNB1. The size of the dots represent the median VAF across mutated samples.