Extended Data Fig. 7: Changes in the average expression of the ASD genes in RG, IP, and UL cells of control and TSC1/2 cKO cortices. | Nature

Extended Data Fig. 7: Changes in the average expression of the ASD genes in RG, IP, and UL cells of control and TSC1/2 cKO cortices.

From: TSC tunes progenitor balance and upper-layer neuron generation in neocortex

Extended Data Fig. 7: Changes in the average expression of the ASD genes in RG, IP, and UL cells of control and TSC1/2 cKO cortices.The alternative text for this image may have been generated using AI.

(A) Log2-fold changes in high confidence ASD gene expression levels in cKO cells compared to controls are illustrated (P < 0.05, two-tailed hierarchical permutation test). High confidence ASD gene list is from SFARI ASD gene database (https://gene.sfari.org/). SFARI genes with no significant expression changes in any of the 3 cell classes are not included. RGC, radial glial cells; IP, intermediate precursors; UL, upper layer neurons. Circle size indicates the value of log fold change. Red-blue gradient indicates the direction of change.

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