Extended Data Fig. 2: Changes in brain weight and cortical size in TSC1/2 cKO.
From: TSC tunes progenitor balance and upper-layer neuron generation in neocortex
(A,B) Increased brain size and weight (C) in TSC1/2 cKO (n = 5 mice/group). (D-F) Increased width (yellow bar) of cerebral cortical wall in TSC1/2 cKO (n = 8 mice/group). (G) Change in cortical size is also reflected in increased cortical circumference [somatosensory cortex level] in TSC1/2 cKO (n = 7 mice/group). Data shown are mean ± SEM. Unpaired two-sided t-test; *p < 0.05, **p < 0.01, and ***p < 0.001 [p = 0.0147 (C), 0.0036 (F), 0.0009 (G)]. Scale bar: A-B (1 mm); D-E (500 μm).
