Fig. 2: External trait genetic correlations for psychiatric factors.

Point estimates for the r_gs between 14 external traits and the 5 psychiatric factors from the correlated factors model and the p-factor from the hierarchical model. These traits were selected as they were significantly correlated with at least one factor at >0.35 or <−0.35. Bars depicted with a dashed outline were significant for the Q_Trait heterogeneity statistic, which indicates that the pattern of r_gs for that trait did not fit the factor structure. Bars depicted with an asterisk reflect values that were significant at a Bonferroni-corrected threshold for multiple comparisons, that were also not significant at this same Bonferroni corrected threshold for Q_Trait. This is with the exception that the p-factor is depicted with an asterisk even if it is significant for the Q_Trait, provided that the same trait was significantly correlated with the majority (at least three) of the five other factors. The two-sided P values used to evaluate significance were derived from the Z-statistics, calculated as the point estimate of the r_g divided by its s.e. Error bars are ±1.96 s.e., centred around the point estimate of the r_gs. Traits are ordered by the point estimate for the p-factor. The implied sample size for the psychiatric factors was: Compulsive (\(\hat{n}\) = 54,100), SB (\(\hat{n}\) = 127,202), Neurodevelopmental (\(\hat{n}\)  = 84,760), Internalizing (\(\hat{n}\) = 1,637,337), SUD (\(\hat{n}\) = 313,395) and p-factor (\(\hat{n}\) = 2,168,621). Sample sizes for the external traits are reported in Supplementary Table 12 and exact P values are reported in Supplementary Table 13.