Extended Data Fig. 3: External trait genetic correlations: Comparison within factors.

Bar graphs depict genetic correlations with the 31 complex traits that are ordered by magnitude within each factor for the five psychiatric factors from the correlated factors model and the second-order, p-factor from the hierarchical model. Bars depicted with a dashed outline for the Q_Trait heterogeneity metric. Bar depicted with a * reflect values that were significant at a Bonferroni corrected threshold for multiple comparisons, that were also not significant at this same Bonferroni corrected threshold for Q_Trait. This is with exception of the p-factor, which is depicted with a ‘*’ even if it is significant for the Q_Trait, as long as that same trait was significantly correlated with the majority (at least three) of the five other factors. The two-sided P-values used to evaluate significance were derived from the Z-statistics, calculated as the point estimate of the genetic correlation divided by its standard error. Error bars are +/− 1.96 SE that are centred around the point estimate of the genetic correlations. The implied sample size for the psychiatric factors was: Compulsive (\(\hat{n}\) = 54,100); Schizophrenia/Bipolar (\(\hat{n}\) = 127,202); Neurodevelopmental (\(\hat{n}\)  = 84,760); Internalizing (\(\hat{n}\) = 1,637,337); Substance Use (\(\hat{n}\) = 313,395); p-factor (\(\hat{n}\) = 2,168,621). See Suppl. Table 12 for sample sizes for the external traits and Suppl. Table 13 for exact P-values.