Extended Data Fig. 4: Stratified Genomic SEM results.

Bar graph depicts the enrichment results for different brain cell types, protein-truncating variant intolerant (PI) genes, and the intersection across PI genes and brain cell types. Results are shown only for the SB, Internalizing, and p-factor due to the limited signal for the other factors. Enrichment for height is depicted in purple to benchmark results and evaluate specificity in signal for the psychiatric factors relative to another human complex trait. Error bars are +/- 1.96 SE that are centred around the enrichment point estimate. Enrichment estimates that were significant at a strict Bonferroni corrected threshold for multiple comparisons are shown with a *. The one-sided P-values used to evaluate significance were derived from the Z-statistics, calculated as the enrichment point estimate divided by its standard error. Exact P-values are reported in Suppl. Table 50. The implied sample size for the psychiatric factors was: Compulsive (\(\hat{n}\) = 54,100); Schizophrenia/Bipolar (\(\hat{n}\) = 127,202); Neurodevelopmental (\(\hat{n}\)  = 84,760); Internalizing (\(\hat{n}\) = 1,637,337); Substance Use (\(\hat{n}\) = 313,395); p-factor (\(\hat{n}\) = 2,168,621).