Extended Data Table 1 Summary of Psychiatric Disorder Datasets
From: Mapping the genetic landscape across 14 psychiatric disorders
- The table is ordered with respect to the liability scale heritabilities (within each genetic ancestry). The Neffective column reports the sum of effective sample sizes across contributing cohorts. Nicotine dependence includes a single value for the sample size columns as this was the one continuous measure, defined using the Fagerström Test for Nicotine Dependence. The reported population prevalences were taken from the corresponding univariate publication when possible and were used for liability scale conversions (possible scale = 0–100%). The numbers in parentheses in the liability scale heritability column reflect the corresponding standard errors. The GWAS loci column reports the number of independent significant hits. A genome-wide significance threshold of P < 5 × 10−8 was employed to correct for multiple statistical comparisons, and significance was evaluated using two-sided P values obtained from Z-statistics, which reflected the estimated univariate GWAS beta over its estimated standard error. Results are shown for: Tourette’s Syndrome18, Schizophrenia17,30, Cannabis Use Disorder26, Bipolar Disorder13, Attention-Deficit/Hyperactivity Disorder15, Anorexia Nervosa14, Obsessive Compulsive Disorder19, Alcohol Use Disorder21,31, Autism Spectrum Disorder16, Anxiety Disorders22, Nicotine Dependence24, Major Depression20,29, Opioid Use Disorder25, and Post-traumatic Stress Disorder23.
