Extended Data Fig. 4: Dynamic SBS mutational processes during early and late tumour evolution.
From: Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma
Fold changes between the relative proportions of early and late clonal mutations attributed to individual SBS mutational signatures. Box plots display the median (centre line), interquartile range (box), and whiskers extending to 1.5× the IQR. Each point represents a tumour sample (n = 542) and is coloured by mutational signature. P values from two-sided Wilcoxon rank-sum tests are shown below the box plots.
