Extended Data Fig. 8: Validation of the association between L1 retrotransposition and mutational signatures ID2 using WGS data from normal and matched colorectal cancer clones32.
From: Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma
Scatter plots show Pearson correlations between the number of somatic L1 insertions and the number of ID1/ID2 mutations in normal colorectal epithelium (red), matched colorectal cancer (blue), and MUTYH-associated adenomatous polyps (orange). Spearman correlation coefficients (R) and p-values (P) are indicated in the plots. The fitted regression line (blue) and 95% confidence intervals (grey) are shown.
