Extended Data Fig. 2: Overview of the molecular timing distribution of copy number gains per chromosome.

a, Pie charts depict the distribution of the inferred mutation time for a given copy number gain in a group. Green denotes early clonal gains, with a gradient to purple for late gains. The size of each pie chart is proportional to the frequency of recurrence of each event. b, Comparison of the molecular timing of copy number gains on chromosomes 21 and 22 versus other chromosomes across all three groups. c, Comparison of the molecular timing of copy number gains on chromosome X versus other chromosomes in tumours from the EU_S group. Two-sided Wilcoxon rank-sum test p-values are shown above the box plots. All box plots show the median (centre line), IQR (box), and whiskers extending to 1.5× the IQR by default in ggplot2. The P-values derived from the two-sided Wilcoxon rank-sum test are shown above the box plots.