Extended Data Fig. 3: Further human T cell response dissection.
From: Multi-omics analysis of a pig-to-human decedent kidney xenotransplant
A-C. Human T cell subtypes found in 5.1k ST data (2595 cells), as shown via dimension reduction plot (A), percentage across all cells in each timepoint (B), and marker genes defining these cells (C). D. Cell-type markers of PBMC NK and T cells populations. E. Proportion of proliferative human NK cells found in the 5.1k ST data. F-G. Proportions (F) and marker gene expression (G) of human CD8T and CD4T from the 478 panel ST data. H. Distribution of T and NK subtypes found in the PBMC scRNAseq data, as percentage of all cells across timepoints (for subtypes not shown in Fig. 4). (H). I. Percentage of human Dividing and T cells found in snRNAseq data. J. Expression levels of CD8T markers (CD8A, CD8B, top) and Tregs markers (RTKN2, CTLA4, bottom), from PBMC bulk RNAseq. Treatment with rATG is annotated with red marks. K. Flow cytometry T cells distributions, CD8+ T cells (middle) and CD4+ T cells (bottom), separated by central memory and effector memory cells.
