Extended Data Fig. 9: Model of immune defense via tRNA trimming by Cas12a3.
From: RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity
From left to right: Stepwise activation of Ba1Cas12a3 and tRNA cleavage leading to translational inhibition and growth arrest in response to a recognized target RNA expressed from an invading bacteriophage. The N in the cleaved tRNA tail is the discriminator base.
