Extended Data Fig. 7: ZOE DIET ranks and their associations with BMI.

a) Comparison of the ZOE MB Diet-ranks (x-axis) with the Spearman’s partial correlations (corrected for sex and age, y-axis) for the 661 ranked SGBs in the five PREDICT cohorts. b) The number of the 50 most-favorably ranked SGBs (ZOE MB Health-rank, Richness) detected in different BMI categories, showed that increasing BMI, linked with increasing health risks, is reflected by a lower presence of favorable SGBs. On the other hand, c) unfavorably-ranked SGBs show an increasing count in higher-risk BMI categories. d,e) The box plots report the number of the 50 most favorable and unfavorable ZOE MB Diet-ranked SGBs of individuals stratified into three BMI categories (healthy-weight, overweight, and obese) in each PREDICT cohort. f,g) Similarly, the box plots represent the cumulative relative abundance of the 50 most favorable and unfavorable ZOE MB Diet-ranked SGBs in individuals categorized into the three BMI categories in each cohort. h,i) The box plots report the number of the 50 most favorably and most unfavorably ranked SGBs, ranked using the same markers and categories as in the ZOE MB Health-ranks (Methods), but partial correlations were corrected only for sex and age. j,k) Similarly, the box plots report the count of the 50 most favorable and unfavorable SGBs in the three BMI categories, with SGBs ranked according to their partial correlation with BMI, adjusted by sex and age. Only non-significant FDR-corrected P values (ns, P value > 0.01) from the Mann-Whitney U test are reported.