Fig. 2: The 15 top and bottom health-ranked SGBs show consistent associations across the five PREDICT cohorts.
From: Gut micro-organisms associated with health, nutrition and dietary interventions
a, Average percentiles for the 15 most favourably (top) and unfavourably (bottom) ranked SGBs (selected for visualization purposes) across all five PREDICT cohorts. Percentiles are computed from the ranking of the correlations between SGBs and the different markers in each clinical data category. Percentiles close to 0 reflect SGBs consistently correlated positively with positive markers and negatively with negative markers, and vice versa for percentiles close to 1. For each cohort, the average percentiles for three clinical data categories are shown (personal, fasting and postprandial) and the cohort-level average. The rightmost column of the heatmap reports the ZOE MB health-ranks with the distribution of their relative abundance values when present (derived from n = 34,694 participants spanning the five PREDICT cohorts). Box plots as in Fig. 1. b,c, Detailed percentiles for the 15 most favourably and unfavourably ranked SGBs against the markers of the three clinical data categories of the PREDICT 1 (UK) (b) and PREDICT 3 US22A (US) (c) cohorts. Detailed panels of the percentiles for the other three cohorts can be found in Extended Data Fig. 2. iAUC, incremental area under the curve; PUFA, polyunsaturated fatty acid; QUICKI, quantitative insulin sensitivity check index; THR, total-cholesterol-to-HDL ratio; VLDL, very-low-density lipoprotein.
