Extended Data Fig. 8: Gene to program to trait maps, related to Fig. 5.
From: Causal modelling of gene effects from regulators to programs to traits
a) Number of top hits (|γ| > 0.1) for MCH whose direction of associations were concordant or discordant with that predicted from the model. Grey points and their density plot are the results from 20,000 permutations. Red point shows the observed data. b) Distribution of top hits concordance p-values in permutation tests for MCH. In each permutation, we counted the number of top hits concordant with the model and evaluated its enrichment (Methods). The observed result showed the highest concordance compared to permuted sets. c-f) Same plots as (a) and (b), for RDW (c,d) and IRF (e, f). g-h) Gene to program to trait map for RDW (g) and IRF (h).
