Extended Data Fig. 8: MARV16 does not activate FcγRIIa or FcγRIIIa.
From: Potent neutralization of Marburg virus by a vaccine-elicited antibody
a,b, In vitro evaluation of MARV16 mAb-mediated activation of human FcγRIIIa V158 (a) and FcγRIIa H131 (b) using a bioluminescent reporter assay as a surrogate assay for Fc-mediated effector functions. ExpiCHO cells transfected with MARV/Musoke GP and Jurkat-Fcγ cells were used as target and effector cells, respectively.
