Extended Data Fig. 1: GPCRs induce both GTP binding and release from Gα proteins and the process is ligand dependent. | Nature

Extended Data Fig. 1: GPCRs induce both GTP binding and release from Gα proteins and the process is ligand dependent.

From: GTP release-selective agonists prolong opioid analgesic efficacy

Extended Data Fig. 1: GPCRs induce both GTP binding and release from Gα proteins and the process is ligand dependent.

Shown are the radioactivity counts (dpm) without normalization. Means with s.e.m are plotted, and the parameters are presented with 95% CI in Fig. 1, MOR: n = 6 binding, 5 release; KOR: n = 3 binding, 5 release; 5HT1AR: 8 binding, 7 release; M2 n = 3 binding, 3 release; SST2: n = 4 binding, 4 release. Accompanies Fig. 1.

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