Extended Data Table 2 Determination of GTPγS binding in CHO-K1 cells expressing human MOR and βarrestin2 recruitment to the human MOR in U2OS PathHunter® cells from Millipore

From: GTP release-selective agonists prolong opioid analgesic efficacy

  1. See Extended Data Fig. 3b. Pharmacological parameters are presented as the mean pEC50 EMAX (% DAMGO max) and ΔlogR (DAMGO reference) with s.e.m. determined from the mean of individual curves with the number of replicates and error as indicated (n). The mean of the ΔΔlogR with 95% CI is presented and determined by comparing ΔlogR values from GTP binding and βarr2 recruitment using an unpaired, two-tailed t-test.
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