Extended Data Fig. 9: Genetic modifier effect size comparisons between chr19:14.8 Mb long, chr19:14.8 Mb mid-length, and chr2:232.4 Mb mid-length AAAG repeat mutability.
From: Insights into DNA repeat expansions among 900,000 biobank participants
a,c,e, Comparison of effect sizes of genetic modifier haplotypes for three somatic-expansion phenotypes for AAAG repeat expansions in blood. Effect sizes are plotted for index variants (i.e., lead genome-wide significant associations); if a locus reached significance in both of the GWAS being compared, data are shown for the index variant with greater significance. Panels b,d,f show zoom-ins to better visualize associations with smaller effect sizes. Effect sizes are in units of standard deviations. Error bars, 95% CIs. Sample sizes are provided in Supplementary Data 5.
