Extended Data Fig. 10: Somatic mutability of mid-length chr2:232.4 Mb and chr19:14.8 Mb AAAG repeat alleles.
From: Insights into DNA repeat expansions among 900,000 biobank participants
a,b Mean amount of somatic expansion of mid-length chr2:232.2 Mb and chr19:14.8 Mb AAAG repeat alleles (i.e., average increase in repeat length across spanning reads) observed in AoU participants who inherited one allele of the indicated length (19, 20, 21, 22, 23, 24, 25, or 26 repeat units). Plots are stratified by MSH3 genotype (chr5:80638411 G > T). c,d Mean amount of somatic expansion of mid-length chr2:232.2 Mb and chr19:14.8 Mb AAAG repeat alleles observed in UKB participants who inherited one allele of the indicated length; plots are stratified by smoking status. e, Relative expansion rates of mid-length chr2:232.2 Mb AAAG repeats in subsets of UKB participants with different pairwise combinations of smoking status and MSH3 genotype (chr5:80638411 G > T). Sample sizes are shown within the figure panels. Error bars, 95% CIs.
