Extended Data Fig. 4: Transcription factor (TF) binding signatures of different loop clusters in H1 cells.
From: An integrated view of the structure and function of the human 4D nucleome
a. ChIP-Seq binding profiles of selected TFs around both anchors of loops from different clusters. Each row represents one loop. b. Fraction of loop anchors bound versus fold enrichment for 62 TFs. c,d. Chromatin state and TF binding differences between CTCF-bound and CTCF-unbound loops in clusters 3–6. c, Fold enrichment of different ChromHMM states at CTCF-bound versus CTCF-unbound loop anchors. d, Fold enrichment of the top 12 TFs (excluding CTCF) with the highest enrichment scores at CTCF-bound versus CTCF-unbound loop anchors. Values above each bar indicate the percentage of loop anchors overlapping the corresponding TF binding peaks.
