Extended Data Fig. 5
From: An integrated view of the structure and function of the human 4D nucleome
a. Box plots show the distribution of normalized TSA-seq and DamID scores on distinct SPIN states in H1 and HFFc6 cell lines. The number of 25 kb bins in H1 (from left to right) is 11,073, 15,446, 10,002, 18,327, 8,771, 5,129, 6,705, 81,96, and 29,226, respectively. The number of 25 kb bins in HFFc6 (from left to right) is 9,693, 14,111, 9,032, 15,749, 9,018, 18,411, 8,249, 7,900, and 20,712, respectively. Box plot shows median (centre line), interquartile range (IQR; box), and whiskers extending 1.5×IQR. b. A confusion matrix shows the comparison of SPIN states in K562 between the previous version and the new result based on the joint modelling across four cell lines. Note that the new result is based on a new nucleolus TSA-seq data. The numbers in the heatmap indicate the number of 25 kb bins. c. The differences of the distributions of normalized TSA-seq and DamID between any two pairs of SPIN states are tested by the two-sided Wilcoxon rank sum test. Colours of heatmap indicate the p-value under the null hypothesis that two distributions are derived from the same population. P-value is classified as p ≤ 1e-10, 1e-10 <p ≤ 1e-5, 1e-5 <p ≤ 0.05, or p > 0.05.
