Extended Data Fig. 1: Chromatin interaction assays quantitatively differ in detection of small compartment domains.
From: An integrated view of the structure and function of the human 4D nucleome
a. Eigenvector 1 obtained from SPRITE data derived from a range of cluster sizes along a typical genomic loci, showing that small compartments are not detected when data from larger SPRITE clusters is used. b. Examples of Eigenvector 1 profiles obtained from data generated with the different genomic assays indicated. c. Compartmentalization strength calculated with interaction data obtained with different SPRITE clusters, for H1 and HFFc6. e,f. Cumulative distributions of compartment sizes, as detected with Hi-C, Micro-C, ChIA PET, PLAC Seq, and SPRITE (cluster size 2–100) for H1 and HFFc6 cells.
