Fig. 1: Asymmetric synthesis of pyramidal molecules. | Nature

Fig. 1: Asymmetric synthesis of pyramidal molecules.

From: The asymmetric synthesis of an acyclic N-stereogenic amine

Fig. 1: Asymmetric synthesis of pyramidal molecules.The alternative text for this image may have been generated using AI.

a, Approaches to P-stereogenic phosphines, S-stereogenic sulfoxides and bridged O-stereogenic oxonium ions have been established. By contrast, acyclic N-stereogenic amines have not been synthesized previously. b, Examples of configurationally stabilized acyclic, tertiary amines. c, Catalytic asymmetric addition of a silyl ketene acetal to an in situ-generated silylnitronium ion (this work).

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