Extended Data Fig. 8: GLIS3 is required for IAF induction and aberrant collagen deposition during colitis.
From: Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit
(a) Schematic of Glis3f/f mice generated by flanking exon 3 with LoxP for Cre-mediated excision. (b) Percent of starting weight of Glis3f/f and Glis3f/f;Cre mice from Fig. 5a. Filled lines represent s.e.m. Two-way repeated measures ANOVA. (c) UMAP of epithelial, immune, fibroblast, and stromal compartments in Xenium-based spatial profiling of water- and chronic DSS-treated Glis3f/f and Glis3f/f;Cre mice. Illustration in a was created with BioRender (https://biorender.com).
