Extended Data Fig. 6: Additional T cell characterization.

Longitudinal frequency at baseline (BL), before rebound (pre-R), and/or after rebound (post-R1) of: a) Activated (CD38⁺HLA-DR⁺) non-naïve CD8⁺ T cells, b) total CD8⁺ T cells, c) non-naïve CD8⁺ T cells, d) total HIV-specific CD8⁺ T cells (as measured by IFNγ expression after 6-hour in vitro stimulation with HIV Gag, Pol, Nef, or Env peptide pools [responses summed]). e) Fold change (FC) between pre-R and post-R1 in HIV-specific CD8⁺ T cell magnitude. f) Total HIV-specific CD8⁺ T cell proliferative response (as measured by the dilution of the dye, cell trace violet [CTV], after 6-day in vitro stimulation with HIV peptide pools). g) FC between BL and pre-ATI in CD8⁺ T cell proliferation in response to Gag+Pol+Nef+Env peptide pool stimulation. h) CE-specific CD8⁺ T cell proliferative response. Magnitude (i) or proliferative response (j-k) of HIV-specific CD4⁺ T cell responses to Gag+Pol+Nef+Env peptide pools (i-j) or CE peptide pool (k). l) Frequency of Ki67⁺ cells within different CD4⁺ T cell subsets. Within-group differences were not significant in d), f), h), i), j), k) (linear mixed effects models).

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