Fig. 2: bNAb PK and susceptibility predict time to HIV rebound but not post-ART set point.

a, Viral load and modelled bNAb concentrations over time after the second dose of bNAbs in each participant; bNAb line colours: black, 10-1074; grey, VRC07-523LS. At the top of each graph, phenotypic susceptibility of autologous HIV to neutralization by bNAbs (IC₉₀) is depicted in pairs of shaded rectangles (left rectangle, 10-1074; right rectangle, VRC07-523LS). Susceptibility was measured from both cell-associated provirus at baseline (depicted in the left-most rectangles in each graph; grey indicates that the value could not be determined (ND)) as well as from post-rebound plasma virus at multiple timepoints, as indicated. b, The correlation between 10-1074 and VRC07-523LS exposure (area under the bNAb concentration–time curve (AUC) after the second dose of bNAbs) and time to rebound. c, The correlation between bNAb susceptibility (IC₉₀) after rebound and the time to rebound after ATI. d, The correlation between bNAb exposure and the post-rebound viral load set point. Statistical analysis was performed using two-sided Spearman’s correlation (b–d).

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