Extended Data Fig. 9: Extended AND-gate clustering analysis of the multi-input library. | Nature

Extended Data Fig. 9: Extended AND-gate clustering analysis of the multi-input library.

From: Ultra-high-throughput mapping of genetic design space

Extended Data Fig. 9

a, Clustering of the multi-input AND-like behaviour space (top left) and part usage across the clusters. b, AND cluster expression distributions across the 4 input conditions (basal, black; 4-OHT, navy; GZV, orange; Both, green), represented by boxplots outlining the interquartile range (IQR) (box), the median (white band), and the median +/− 1.5x IQR (line ends). Median values are shown to the left of the plot. Sample sizes (n): Cluster A = 11,167, Cluster B = 9,854, and Cluster C = 3,627. c, Cluster stability analysis of compositions in the AND-like behaviour space by computing the cluster similarity index (top) across 100 UMAP projections and cluster calculations, and adjusted rand index (bottom) across every pairwise combination of clustering results across the 100 UMAP projections and cluster calculations.

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