Fig. 2: Variants defining a haplotype spanning SMC1B are associated with incidence of maternal meiotic aneuploidy.
From: Common variation in meiosis genes shapes human recombination and aneuploidy
a, Results of GWAS tests of maternal meiotic aneuploidy and maternal genotype (two-sided binomial GLMM). The dotted line indicates the threshold for genome-wide significance (P = 5 × 10−8). b, Fitted relationship between maternal age and incidence of aneuploidy, stratified by maternal genotype at aneuploidy-associated lead SNP rs6006737. c. Regional Manhattan plot depicting the associated locus on Chr. 22, with points coloured based on pairwise linkage disequilibrium with the lead SNP rs6006737 (diamond). Mbp, megabase pairs.
