Fig. 4: Aneuploidy, recombination and female reproductive ageing traits share an overlapping genetic basis.
From: Common variation in meiosis genes shapes human recombination and aneuploidy
The lead SNP from each peak from GWAS of aneuploidy and recombination was queried for association with other fertility-related phenotypes (two-sided linear or logistic model from respective GWAS study). Darkness indicates significance of association (P value), while colour indicates direction of association. SNPs are polarized such that the aneuploidy-increasing allele is queried across all traits. Each hit is labelled based on meiosis-related candidate genes within the associated region (top) with the exception of the common 17q21.31 inversion, as well as the locus containing ACYP2 and TSPYL6, where no such candidate is apparent.
