Extended Data Fig. 5: Mutational signatures found in acral melanoma samples from Mexican patients.

a) The SNV component of tumour mutational burden per sample. b-c) Proportions of mutational signatures per sample are shown in stacked bars for single base substitutions (b), and copy-number aberrations (c). In b) and c), samples with a light gray background did not have data available. Genomic subtypes and clinical characteristics are plotted at the bottom. As a note, mutational signature CN48F in c) is a de novo mutational signature that was not successfully reconstructed by COSMIC reference mutational signatures, and was therefore considered as novel.