Extended Data Fig. 3: HPCS, uPAR, NKX2.1, and HMGA2 across tumours of distinct histopathological grades. | Nature

Extended Data Fig. 3: HPCS, uPAR, NKX2.1, and HMGA2 across tumours of distinct histopathological grades.

From: Critical role for a high-plasticity cell state in lung cancer

Extended Data Fig. 3: HPCS, uPAR, NKX2.1, and HMGA2 across tumours of distinct histopathological grades.The alternative text for this image may have been generated using AI.

a, Representative H&E and immunohistochemistry (IHC) for Cre (to detect the Slc4a11-MCD reporter), uPAR, NKX2.1 and HMGA2 on serial sections from autochthonous KPfrt; Hipp11GGCB/+; Slc4a11FSF-MCD/+ LUAD tumours at 7 and 16 weeks PTI. Histopathological grades were assigned using Aiforia artificial intelligence (AI)-based image analysis software. Scale bar: 100 µm (low magnification) and 10 µm (high magnification). b, uPAR+ (top), NKX2.1+ (middle), HMGA2+ (bottom) tumour cell percentages across histopathological grades. uPAR: n = 30 tumours per grade, 4 mice; NKX2.1: 28 tumours per grade, 4 mice; HMGA2: 31 tumours per grade, 4 mice. One-way ANOVA with Dunnett’s T3 multiple comparisons test. Error bars are SEM.

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