Extended Data Fig. 1: Parallel differentiation of T_RM and TEX_term and their transactional and epigenetic similarity.

a, UMAP of scRNA-seq data of T cells from blood, tumor, and adjacent normal tissues of CRC⁸⁵, NSCLC⁴⁴, and HCC⁸⁶ patients. Unbiased clustering identified multiple T cell states consistent with those observed murine LCMV infection and tumors. b, T_RM marker genes show higher expression in TEX_term cluster from Pan-cancer scRNA-seq in a. c, Both T_RM and TEX_term clusters upregulate exhaustion-⁸ and T_RM³¹-associated gene signatures. d, Pearson correlation matrix of batch-corrected ATAC-seq datasets^3,9,33,34. Color and size are both proportional to correlation strength. e, A total of 121 experiments across multiple data sets^{3,9,17,22,31,32,33,34,35} were utilized to generate an epigenetic and transcriptional atlas of CD8⁺ T cells under chronic and acute antigen exposure.