Extended Data Fig. 9: Tolerance effects as a function of antigen dose.
From: Environmentally driven immune imprinting protects against allergy
(a) Experimental scheme. Mice were provided with water containing cOVA across a range of concentrations for five days. A week after water bottle removal, mice were sensitized subcutaneously with cOVA in alum. (b) Core body temperature following systemic challenge with cOVA. (c) Maximal temperature loss. (d-e) cOVA-reactive IgE (d) and IgG1 (e) on d24 of the experiment. n = 15 for all panels. Statistical significance was determined using one-way ANOVA with Tukey correction for multiple comparisons (c-e). Error bars represent SD besides (b) (SEM). Data are pooled from two or more repeats of each experiment.
