Extended Data Fig. 4: Contact map prediction and comparison with Orca.
From: Advancing regulatory variant effect prediction with AlphaGenome
(a) Comparison of predicted chromatin contact maps for five randomly selected 1-Mb intervals from the validation set. Rows show ground truth experimental data (H1-hESC Micro-C), predictions from the baseline model Orca, and predictions from AlphaGenome. Pearson correlation coefficients (r) between prediction and ground truth are displayed in the upper right corner of each corresponding predicted map. (b) Scatterplot comparing overall contact map prediction performance of AlphaGenome and Orca across all 1-Mb test intervals, for the two cell-types predicted by Orca. Each point represents an interval, plotting the Pearson R achieved by AlphaGenome (y-axis) versus Orca (x-axis) when comparing predictions to the ground truth. Points above the diagonal indicate intervals where AlphaGenome achieved higher correlation than Orca.
