Extended Data Fig. 5: Enrichment of EBV DNAemia-associated genetic variants in immune populations and pathways.
From: Population-scale sequencing resolves determinants of persistent EBV DNA
(a) Schematic of human hematopoietic differentiation, highlighting 18 populations with fluorescent activated cell sorting (FACS)-isolated populations profiled via ATAC-seq. Color: accessible chromatin enrichment at genome-wide significant non-coding loci. Statistical test: empirical permutation test. (b) UMAP embedding of 211,000 peripheral blood mononuclear cells. The broad cell type annotation (Azimuth level 2) annotates refined cell types. (c) Summary of EBV ExWAS signature stratified by Azimuth L2 cell type, sorted by median score. Boxplots: center line, median; box limits, first and third quartiles; whiskers, 1.5× interquartile range. Sample size: 211,000 cells. (d) Summary of GO Biological Processes and (e) KEGG gene set analyses. Top pathways based on q value and fold enrichment are annotated.
